Possible role of Moringa oleifera Lam. root in epithelial ovarian cancer.

Age-specific incidence of epithelial ovarian cancer indicates a hormonal etiology and relates it to menopause, a time during the aging process when ovaries fail but the pituitary becomes overactive to produce a greater amount of gonadotropins. There is a 10-fold to 20-fold increase in the follicle-stimulating hormone (FSH) level and a 3-fold to 5-fold increase in the luteinizing hormone (LH) level in blood in menopause. Naturally, gonadotropins, especially follicle stimulating hormone (FSH) and its receptor (FSHR), are implicated as endogenous carcinogens for ovarian cancer.